Tuesday, January 10, 2012

Chronic lymphocytic leukamia

Chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL) is a monoclonal disorder characterized by a progressive accumulation of functionally incompetent lymphocytes. It is the most common form of leukemia found in adults in Western countries.
Onset is insidious, and it is not unusual for CLL to be discovered incidentally after a blood cell count is performed for another reason. Enlarged lymph nodes are the most common presenting symptom, but patients may present with a wide range of symptoms and signs.
Chemotherapy is not needed in CLL until patients become symptomatic or display evidence of rapid progression of disease. A variety of chemotherapy regimens are used in CLL. These may include nucleoside analogues, alkylating agents, and biologics, often in combination. Allogeneic stem cell transplantation is the only known curative therapy.

3 comments:

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